Expanded Contour 6
Modules in males and females with MDD are enriched for cell-type specific genes. Stacked bar graphs showing modules enriched for genes expressed in particular cell types in a, male MDD and b, female MDD. The y axis represents module size defined by number of genes within each module. Modules are defined by an arbitrary color name and are clustered by module differential connectivity (MDC) as gain of connectivity (GOC), loss of connectivity (LOC) and conserved. There is no module associated with a LOC in females with MDD. Enrichment is determined by corrected Fisher’s Exact Test p-value and is listed only for modules that reached significance (FDR p<0.05).
Longer Contour seven
Gene co-expression modules in males with MDD are enriched for DEGs across brain regions. a, Topological overlap matrix (TOM) plots for control and b, MDD modules in males. Light color represents low topological overlap and progressively darker red color represents higher overlap. Each module is assigned by a unique color. c, Circos plots displaying the degree of enrichment for DEGs (p<0.05)>Extended Figure 8
a great, Schematic icon of your own behavioral paradigm accustomed measure the feeling out-of DUSP6 downregulation on vmPFC of females. Behavioural consequences regarding DUSP6 downregulation within the girls vmPFC on the b, pressed swimming take to (FST), c, open field take to (OFT), and you may d, elevated as well as network (EPM). elizabeth, Schematic signal of your own behavioral paradigm http://datingmentor.org/chinalovecupid-review/ accustomed gauge the effect of DUSP6 overexpression in females adopting the sub-chronic variable fret. Bottom chart shows new HSV-mediated overexpression regarding DUSP6 covering the infra- and you may prelimbic area of the vmPFC when you look at the rats.